In 1942, Northwest was assigned ten of the capacious C-46 cargo haulers to fly through the Northern Region to support the defense of Alaska and the Lend-Lease supply chain to the Soviet Union. The airframe was already sturdy, but NWA continued to adapt it for cold-weather operation, as well as improvising methods of maintenance in extreme conditions. One airframe was lost in September 1943, but the rest survived. As the war came to a close, all C-46s were returned to military hands; none ever flew in Northwest colors.
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